General Notes
This product (Catalog No. DPABH-14367) is a rabbit-derived IgG polyclonal antibody raised against human TLR4, targeting the amino acid region 701–800 of the protein. This antibody exhibits cross-reactivity with TLR4 from mouse, rat, cow, pig, horse, rabbit, and sheep. It has been affinity purified by Protein A. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene.
DPABH-14367 is suitable for use in Western blot (WB) (1:1,000–1:2,000), IHC-P (1:100–1:500), IHC-F (1:500–1:1,000), IF (immunofluorescence) (1:200–1:1,000) applications.
DPABH-14367 is supplied as a liquid formulation in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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