Anti-TICRR polyclonal antibody (DPABH-21930)

Rabbit anti-Human TICRR (aa 975-1025) polyclonal antibody for WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Synthetic peptide, corresponding to a region within amino acids 975-1025 of Human C15orf42 (NP_689472.3).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500 - 1/2500.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
TICRR; TOPBP1-interacting checkpoint and replication regulator; SLD3; Treslin; C15orf42; treslin
Entrez Gene ID
UniProt ID

Product Background


Gene summary
TICRR (TOPBP1 Interacting Checkpoint And Replication Regulator) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. Treslin is involved in the initiation of DNA replication (Kumagai et al. , 2010 [PubMed 20116089]).
Antigen Description
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating to CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. The function about TICRR antigen include chromatin binding; protein binding.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Liu, K; Luo, YH; et al. TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival. GENES & DEVELOPMENT 18:673-686(2004).
Sansam, CL; Cruz, NM; et al. A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. GENES & DEVELOPMENT 24:183-194(2010).

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