Anti-THRB (aa 1-199) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant fragment, corresponding to a region within amino acids 1-199 of Human Thyroid Hormone Receptor beta 1 (UniProt: P10828).

Conjugate

Application Notes

WB: 1/500 - 1/3000; ICC/IF: 1/100 - 1/1000;

Alternative Names

THRB; thyroid hormone receptor, beta; GRTH; PRTH; THR1; ERBA2; NR1A2; THRB1; THRB2; C-ERBA-2; C-ERBA-BETA; thyroid hormone receptor beta; oncogene ERBA2; nuclear receptor subfamily 1 group A member 2; thyroid hormone nuclear receptor beta variant 1; thyro

Entrez Gene ID

UniProt ID

Antigen Description

Thyroid hormone receptors (TRs) are ligand dependent members of the steroid/retinoic acid superfamily of transcription factors. The two genes encoding TRs identified to date, TR alpha and TR beta, have been mapped to human chromosomes 17 and 3, respectively. TRs bind to thyroid hormone response elements (TREs) with half site binding motifs in the orientation of palindromes, direct repeats, or inverted palindromes. The affinities of binding are both variable and influenced differentially by 3,5,3 triiodo L thyronine (T3). Thyroid hormones, through their interaction with the thyroid receptor (TR), effect metabolic processes, growth and development in many tissues by regulating the expression of genes for growth hormone, malic enzyme and several hepatic proteins.

Pathway

Gene Expression; Neuroactive ligand-receptor interaction; Nuclear Receptor transcription pathway; SIDS Susceptibility Pathways