TGIF2 (NP_068581, 131 a.a. ~ 236 a.a) partial recombinant protein with GST tag. The sequence is SMPLHSGQGEKPAAPFPRGELESPKPLVTPGSTLTLLTRAEAGSPTGGLFNTPPPTPPEQ DKEDFSSFQLLVEVALQRAAEMELQKQQDPSLPLLHTPIPLVSENP
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene.
Pathway
Disease; Gene Expression; Loss of Function of SMAD2/3 in Cancer; Loss of Function of TGFBR1 in Cancer
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