Anti-TGIF1 monoclonal antibody, clone 2C23

Antibody Isotype

IgG1

Clone

2C23

Species Reactivity

Human

Immunogen

Recombinant full length protein corresponding to Human TGIF aa 1-272.Sequence: MKGKKGIVAASGSETEDEDSMDIPLDLSSSAGSGKRRRRGNLPKESVQIL RDWLYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRK DGKDPNQFTISRRGAKISETSSVESVMGIKNFMPALEETPFHSCTAGPNP TLGRPLSPKPSSPGSVLARPSVI

Conjugate

Application Notes

WB: 1/2000; IHC-P: 1/150;

Alternative Names

TGIF1; TGFB-induced factor homeobox 1; HPE4, TGFB induced factor (TALE family homeobox) , TGIF; homeobox protein TGIF1; homeobox protein TGIF; 5-TG-3 interacting factor; 5-TG-3-interacting factor 1; TALE homeobox TG-interacting factor; transforming growt

Entrez Gene ID

UniProt ID

Antigen Description

Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down modulation of the RXR alpha activities.

Pathway

Androgen Receptor Signaling Pathway, organism-specific biosystem; Coregulation of Androgen receptor activity, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Id Signaling Pathway, organism-specific biosystem; Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem; TGF Beta Signaling Pathway, organism-specific biosystem; TGF-beta Receptor Signaling Pathway, organism-specific biosystem;