Specifications
Species Reactivity
Mouse; Rat; Human
Immunogen
A synthetic peptide corresponding to residues in Human DP1.
Applications
Application Notes
WB: 1/10000 - 1/50000; Flow Cyt: 1/10 - 1/100;
Target
Alternative Names
TFDP1; transcription factor Dp-1; Dp 1; DP1; DRTF1; DRTF1-polypeptide 1; E2F dimerization partner 1; E2F-related transcription factor; Dp-1;
Product Background
Antigen Description
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5-TTTC[CG]CGC-3, found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F-1/DP complex appears to mediate both cell proliferation and apoptosis.
Pathway
Activation of BH3-only proteins, organism-specific biosystem; Activation of NOXA and translocation to mitochondria, organism-specific biosystem; Activation of PUMA and translocation to mitochondria, organism-specific biosystem; Apoptosis, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem.
Citations
Publication ()
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COA
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