Anti-TFB2M (aa 81-94) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat

Immunogen

Synthetic peptide: RNLVRDLLEHQNPS with a Cysteine residue linker, corresponding to internal sequence amino acids 81-94 of Mouse TFB2M (NP_032275.2).

Conjugate

Application Notes

WB: 0.5 - 2 μg/ml.

Alternative Names

TFB2M; transcription factor B2, mitochondrial; dimethyladenosine transferase 2, mitochondrial; mTFB2M; mtTFB2; house-keeping protein 1; mitochondrial 12S rRNA dimethylase 2; mitochondrial transcription factor B2; S-adenosylmethionine-6-N, N-adenosyl(rRNA)

Entrez Gene ID

UniProt ID

Antigen Description

S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.

Pathway

Gene Expression; Mitochondrial Gene Expression; Mitochondrial transcription initiation; RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription; Transcription from mitochondrial promoters.