Anti-TEF monoclonal antibody Made to order

Name: Anti-TEF monoclonal antibody
SKU: DCABH-13734
Rating: 5 (1 reviews)

Rabbit anti-Human TEF monoclonal antibody for WB, ELISA

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COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human TEF is used for rabbit immunization.

Conjugate

Unconjugated

Target

Alternative Names

TEF; thyrotrophic embryonic factor; thyrotroph embryonic factor; KIAA1655;

Entrez Gene ID

7008

UniProt ID

Q10587

Product Background

Antigen Description

Thyrotroph embryonic factor (TEF), a transcription factor, is a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Documents

pdf COA

pdf SDS

pdf Datasheet

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References

Human placental 3 beta-hydroxysteroid dehydrogenase/steroid Delta 5,4-isomerase 1: Identity, regulation and environmental inhibitors

TOXICOLOGY

Authors: Zhu, Qiqi; Pan, Peipei; Chen, Xiuxiu; Wang, Yiyan; Zhang, Song; Mo, Jiaying; Li, Xiaoheng; Ge, Ren-Shan

Abstract

Human placental 3 beta-hydroxysteroid dehydrogenase/steroid Delta 5, 4-isomerase 1 (HSD3B1), a high-affinity type I enzyme, uses pregnenolone to make progesterone, which is critical for maintenance of pregnancy. HSD3B1 is located in the mitochondrion and the smooth endoplasmic reticulum of placental cells and is encoded by HSD3B1 gene. HSD3B1 contains GATA and TEF-5 regulatory elements. Many endocrine disruptors, including phthalates, methoxychlor and its metabolite, organotins, and gossypol directly inhibit placental HSD3B1 thus blocking progesterone production. In this review, we discuss the placental HSD3B1, its gene regulation, biochemistry, subcellular location, and inhibitors from the environment.

'Embedded into the core': The discursive construction of 'policy' in higher education learning and teaching documents and its recontextualisation in practices

DISCOURSE & SOCIETY

Authors: Horrod, Sarah

Abstract

With increasing competition and metrics focusing on teaching quality (e.g. the teaching excellence framework or TEF), there is a spotlight on learning and teaching (L&T) in policies and practices within universities. Bodies at national and institutional levels focus on disseminating policy ideas on L&T which are oriented to government priorities. This article focuses on how policy itself is discursively constructed in selected L&T policy documents and explores the means of the recontextualisation of policy discourses. I discuss the following three findings: (1) the construction of policy as 'embedded within processes and practices', (2) shifts in genre and discursive strategies as policy ideas become short guidelines and (3) the role of 'discursive mechanisms' in forcing engagement with policy ideas. Through an analysis of discursive strategies and recontextualisation, I demonstrate the seeming insecurity around policy compliance and show how constructions of L&T are never value-free.