Specifications
Immunogen
Recombinant fragment corresponding to a region within amino acids 126-416 of the Human TEAD4 protein (Q15561).
Applications
Application Notes
WB: 1/500 - 1/3000; ICC/IF: 1/100 - 1/1000.
Target
Alternative Names
TEAD4; TEA domain family member 4; TCF13L1; transcriptional enhancer factor TEF-3; EFTR 2; RTEF 1; TEF 3; TEFR 1; transcription factor RTEF-1; transcription factor 13-like 1; transcriptional enhancer factor 3; related transcription enhancer factor 1B; tra
Product Background
Antigen Description
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC enhansons (5-GTGGAATGT-3) and activates transcription. Binds to the M-CAT motif.
Pathway
Fatty acid, triacylglycerol, and ketone body metabolism; Gene Expression; Generic Transcription Pathway; Metabolism; Metabolism of lipids and lipoproteins; PPARA Activates Gene Expression; Regulation of Lipid Metabolism by Peroxisome proliferator-activate
Citations
Publication ()
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COA
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