Anti-TCEB1 (full length) polyclonal antibody

Species Reactivity

Human

Immunogen

TCEB1 (AAH13809, 1 a.a. ~ 112 a.a) full-length recombinant protein with GST tag. The sequence is MDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEV NFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC

Conjugate

Alternative Names

TCEB1; transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); SIII; eloC; transcription elongation factor B polypeptide 1; SIII p15; elongin 15 kDa subunit; RNA polymerase II transcription factor SIII subunit C;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.

Pathway

Adaptive Immune System; Proteasome degradation; Cellular responses to stress; presentation