Anti-TBK1 monoclonal antibody (DCABH-462)
Mouse anti-Human TBK1 monoclonal antibody for WB, IHC-P
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Synthetic peptide: YYQFKKDKAERRLAYC conjugated to KLH, corresponding to amino acids 563-577 of Human NAK (NP_037386.1).
WB: 1 - 2 μg/ml; IHC-P: 10 μg/ml;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
TBK1; TANK-binding kinase 1; serine/threonine-protein kinase TBK1; NAK; NF-kB-activating kinase; NF-kappa-B-activating kinase
Activated TLR4 signalling, organism-specific biosystem; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, organism-specific biosystem; Cytosolic DNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensing pathway, conserved biosystem; Cytosolic sensors of pathogen-associated DNA, organism-specific biosystem; DAI mediated induction of type I IFNs, organism-specific biosystem; Hepatitis C, organism-specific biosystem;
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Oganesyan, G; Saha, SK; et al. IRF3-dependent type I interferon response in B cells regulates CpG-mediated antibody production. JOURNAL OF BIOLOGICAL CHEMISTRY 283:802-808(2008).
Jin, J; Xiao, YC; et al. The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-kappa B signaling. NATURE IMMUNOLOGY 13:1101-1109(2012).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.