Anti-TAS2R8 monoclonal antibody (DCABH-13706) Made to order

Rabbit anti-Human TAS2R8 monoclonal antibody for WB, ELISA

View other TAS2R8 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human TAS2R8 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
TAS2R8; taste receptor, type 2, member 8; taste receptor type 2 member 8; T2R8; TRB5; taste receptor family B member 5
Entrez Gene ID
UniProt ID

Product Background


Gene summary
TAS2R8 (Taste 2 Receptor Member 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is TAS2R42. This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.
Antigen Description
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. Taste receptor type 2 member 8 is a protein that in humans is encoded by the TAS2R8 gene. The function about TAS2R8 antigen include receptor activity; signal transducer activity; taste receptor activity.
Pathway
Taste transduction, organism-specific biosystem; Taste transduction, conserved biosystem.

Citations


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References


Di Giulio, A; Maurizi, E; et al. Functional structure of antennal sensilla in the myrmecophilous beetle Paussus favieri (Coleoptera, Carabidae, Paussini). MICRON 43:705-719(2012).
Akao, H; Polisecki, E; et al. KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly. ATHEROSCLEROSIS 220:456-462(2012).

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