Rabbit Anti-Human TAGLN Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse; Rat

Immunogen

Recombinant fusion protein of human TAGLN (NP_001001522.1).

Conjugate

Application Notes

WB: 1:500-1:2000
IHC: 1:50-1:200
IF: 1:50-1:100

General Notes

This product (Catalog No. DPABH-27301) is a rabbit-derived polyclonal antibody raised against human TAGLN. This antibody exhibits cross-reactivity with TAGLN from mouse and rat. It has been affinity purified by Protein A. This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization.
DPABH-27301 is suitable for use in Western blot (WB) (1:500–1:2,000), IHC (1:50–1:200), IF (immunofluorescence) (1:50–1:100) applications.
DPABH-27301 is supplied as a liquid formulation in PBS with 0.02% sodium azide,50% glycerol,pH7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

TAGLN; SM22; SMCC; TAGLN1; WS3-10

Entrez Gene ID

UniProt ID