Anti-TAF9 monoclonal antibody, clone FQS23186(C)

Antibody Isotype

IgG

Clone

FQS23186(C)

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide corresponding to residues in Human TAF9, (Uniprot ID: Q16594)

Conjugate

Application Notes

WB: 1/1000 - 1/10000; ICC/IF: 1/100 - 1/250.

Alternative Names

TAF9; TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa; TAF2G, TATA box binding protein (TBP) associated factor, RNA polymerase II, G, 32kD; adenylate kinase isoenzyme 6; AD 004; adenylate kinase 6; AK6; CGI 137; CINAP; coi

Entrez Gene ID

UniProt ID

Antigen Description

TAF9 functions as a component of the DNA-binding general transcription factor complex TFIID and the regulatory transcription complex SAGA. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3 and SPT8) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3, and TRA1), and chromatin modification through histone acetylation (GCN5).

Pathway

Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; C-MYC pathway, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; Disease, organism-specific biosystem; Eukaryotic Transcription Initiation, organism-specific biosystem; Gene Expression, organism-specific biosystem.