Anti-TAF6 (aa 38-87) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Human

Immunogen

A region within synthetic peptide: LLTDEVSYRI KEIAQDALKF MHMGKRQKLT TSDIDYALKL KNVEPLYGFH, corresponding to N terminal amino acids 38-87 of Human TAF6

Conjugate

Application Notes

WB: 1.25 μg/ml; IHC-P: 4 - 8 μg/ml.

Alternative Names

TAF6; TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa; TAF2E, TATA box binding protein (TBP) associated factor, RNA polymerase II, E, 70/85kD; transcription initiation factor TFIID subunit 6; MGC:8964; TAF6 RNA polymerase I

Entrez Gene ID

UniProt ID

Antigen Description

TAF6 is a subunit of transcription factor IID (TFIID). Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. TAF6 is one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis.

Pathway

Basal transcription factors; Disease; Eukaryotic Transcription Initiation; Gene Expression; HIV Infection; HIV Life Cycle;