Anti-TAF10 (aa 1-218) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant full length protein corresponding to amino acids 1-218 of Human TAF10 (NP_006275.1).

Conjugate

Application Notes

WB: 1/500 - 1/1000; ICC/IF: 10 μg/ml.

Alternative Names

TAF10; TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa; TAF2A, TAF2H, TATA box binding protein (TBP) associated factor, RNA polymerase II, H, 30kD; transcription initiation factor TFIID subunit 10; TAFII30; STAF28; TAFII-3

Entrez Gene ID

UniProt ID

Antigen Description

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. TAF10 is one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs.

Pathway

Basal transcription factors; C-MYC pathway; Disease; Gene Expression; HIV Infection; HIV Life Cycle;