Anti-TAB1 (center domain) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

a synthetic peptide corresponding to 13 amino acids in the center of human TAB1.

Conjugate

Alternative Names

TAB1; TGF-beta activated kinase 1/MAP3K7 binding protein 1; 3'-Tab1; MAP3K7IP1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TAK1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1; mitogen-activated protein

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Pathway

Activated TLR4 signalling; Cytokine Signaling in Immune system; Epstein-Barr virus infection; FCERI mediated NF-kB activation; Fc epsilon receptor (FCERI) signaling; Herpes simplex infection; IL1-mediated signaling events; IRAK2 mediated activation of TAK1 complex