Anti-SLITRK1 (aa 450-675) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant fragment, corresponding to a region within amino acids 450-675 of Human Slitrk1 (UniProt: Q96PX8).

Conjugate

Application Notes

WB: 1/500 - 1/3000.

Alternative Names

SLITRK1; SLIT and NTRK-like family, member 1; leucine rich repeat containing 12; LRRC12; SLIT and NTRK-like protein 1; KIAA1910; slit and trk like gene 1; leucine-rich repeat-containing protein 12; TTM; LRRC12; FLJ54428; KIAA0918; RP11-395N17.1;

Entrez Gene ID

UniProt ID

Antigen Description

Slitrk1 is a member of a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette's Syndrome, it is thought to play only a minor role if at all.