Anti-SYVN1 (aa 495-506) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to Human SYVN1 aa 495-506 (internal sequence) (Cysteine residue).Sequence: HERQHLEARLQS Database link: Q86TM6

Conjugate

Application Notes

WB: 1 - 3 μg/ml.

Alternative Names

SYVN1; synovial apoptosis inhibitor 1, synoviolin; E3 ubiquitin-protein ligase synoviolin; HRD1; KIAA1810; MGC40372;

Entrez Gene ID

UniProt ID

Antigen Description

Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.

Pathway

Activation of Chaperone Genes by XBP1(S); Activation of Chaperones by IRE1alpha; Diabetes pathways; Disease; HRD1/SEL1 ERAD complex; Protein processing in endoplasmic reticulum;