Synthetic peptide: DEDEIHPLLIRDR-C (with a Cysteine residue linker), corresponding to N terminal amino acids 60-72 of Human SynGAP (NP_006763.2; Q96PV0).
Conjugate
Unconjugated
Applications
Application Notes
WB: 1 - 3 μg/ml.
Target
Alternative Names
SYNGAP1; synaptic Ras GTPase activating protein 1; MRD5; RASA1; RASA5; SYNGAP; ras/Rap GTPase-activating protein SynGAP; neuronal RasGAP; Ras GTPase-activating protein SynGAP; synaptic Ras GTPase-activating protein 1; synaptic Ras GTPase activating protei
Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits.
Pathway
Ras signaling pathway.
Citations
Publication ()
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