Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder
JOURNAL OF NEURAL TRANSMISSION
Authors: Viola, Thiago Wendt; Schuch, Jaqueline Bohrer; Rovaris, Diego Luiz; Genovese, Rafael; Tondo, Lucca; Sanvicente-Vieira, Breno; Zaparte, Aline; Cupertino, Renata Basso; da Silva, Bruna Santos; Dotto Bau, Claiton Henrique; Grassi-Oliveira, Rodrigo
Abstract
The SNP rs2251214 of the SYT1 gene was recently associated with externalizing phenotypes, including ADHD and cocaine use disorder (CUD). Here, we investigated whether SYT1-rs2251214 could also be implicated with cognitive performance variations among women with CUD. Results showed that G homozygous (n = 146) have lower cognitive performance in the Stroop, Trail Making and Matrix Reasoning tests compared with A-allele carriers (n = 64), suggesting that rs2251214 may influence the severity of cognitive impairments in CUD.
Genome-Wide Association Scan of the Time to Onset of Attention Deficit Hyperactivity Disorder
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
Authors: Lasky-Su, Jessica; Anney, Richard J. L.; Neale, Benjamin M.; Franke, Barbara; Zhou, Kaixin; Maller, Julian B.; Arias Vasquez, Alejandro; Chen, Wai; Asherson, Philip; Buitelaar, Jan; Banaschewski, Tobias; Ebstein, Richard; Gill, Michael; Miranda, Ana; Mulas, Fernando; Oades, Robert D.; Roeyers, Herbert; Rothenberger, Aribert; Sergeant, Joseph; Sonuga-Barke, Edmund J. S.; Steinhausen, Hans Christoph; Taylor, Eric; Daly, Mark; Laird, Nan; Lange, Christoph; Faraone, Stephen V.
Abstract
A time-to-onset analysis for family-based samples was performed on the genomewide association (GWAS) data for attention deficit hyperactivity disorder (ADHD) to determine if associations exist with the age at onset of ADHD. The initial dataset consisted of 958 parent-offspring trios that were genotyped on the Perlegen 600,000 SNP array. After data cleaning procedures, 429,981 autosomal SNPs and 930 parent-offspring trios were used found suitable for use and a family-based logrank analysis was performed using that age at first ADHD symptoms as the quantitative trait of interest. No SNP achieved genome-wide significance, and the lowest P-values had a magnitude of 10(-7). Several SNPs among a pre-specified list of candidate genes had nominal associations including SLC9A9, DRD1, ADRB2, SLC6A3, NFIL3, ADRB1, SYT1, HTR2A, ARRB2, and CHRNA4. Of these findings SLC9A9 stood out as a promising candidate, with nominally significant SNPs in six distinct regions of the gene. (c) 2008 Wiley-Liss, Inc.
COA
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