Synthetic peptide within Human SUV3L1 aa 736-786 (C terminal). The exact sequence is proprietary. NP_003162.2Sequence: RLVQQ GLLTPDMLKQ LEKEWMTQQT EHNKEKTESG THPKGTRRKK KEPDSD Database link: Q8IYB8
Conjugate
Unconjugated
Applications
Application Notes
IP: 2-5 μg/mg; WB: 1/2000 - 1/10000;
Target
Alternative Names
SUPV3L1; suppressor of var1, 3-like 1 (S. cerevisiae); SUV3; ATP-dependent RNA helicase SUPV3L1, mitochondrial; SUV3-like protein 1; suppressor of var1, 3-like 1(SUV3); suppressor of var1 3-like protein 1;
Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3 overhang double-stranded RNA with a 3-to-5 directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5-to-3 direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.
Citations
Publication ()
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