Recombinant full length protein corresponding to Human LYK5 aa 1-348. Isoform 2. (NP_699166.2).Sequence: MSFLTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNL ARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATF IADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDY
Conjugate
Unconjugated
Applications
Application Notes
WB: 1 μg/ml;
Target
Alternative Names
STRADA; STE20-related kinase adaptor alpha; LYK5; PMSE; Stlk; STRAD; NY-BR-96; STE20-related kinase adapter protein alpha; STRAD alpha; protein kinase LYK5; STE20-like pseudokinase; serologically defined breast cancer antigen NY-BR-96;
Members of the STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. LYK5 is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating the tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. LYK5-LKB1 interaction results in phosphorylation of LYK5 and enhanced autophosphorylation of LKB1.
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