Anti-STEAP1 monoclonal antibody (DMABT-H28843)

Mouse anti-Human STEAP1 monoclonal antibody for WB, IF, IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
QK3E3BU
Species Reactivity
Human
Immunogen
Anti-human STEAP1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human STEAP1 amino acids 1-70 purified from E. coli.
Conjugate
Unconjugated

Target


Alternative Names
STEAP1; six transmembrane epithelial antigen of the prostate 1; six transmembrane epithelial antigen of the prostate , STEAP; metalloreductase STEAP1; PRSS24; six-transmembrane epithelial antigen of prostate 1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
STEAP1 (Six Transmembrane Epithelial Antigen Of The Prostate 1) is a Protein Coding gene. Among its related pathways are Mineral absorption. GO annotations related to this gene include oxidoreductase activity and channel activity. An important paralog of this gene is STEAP2. This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.
Antigen Description
STEAP1 is principally expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The STEAP1 is predicted a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctionMetalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity). Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene. 0The function about STEAP1 antigen include channel activity; electron carrier activity; flavin adenine dinucleotide binding; iron ion binding; metal ion binding; oxidoreductase activity; transporter activity.
Pathway
Mineral absorption, organism-specific biosystem; Mineral absorption, conserved biosystem.

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