Specifications
Species Reactivity
Mouse; Rat; Rabbit; Guinea pig; Cow; Human
Immunogen
Recombinant fragment, corresponding to N terminal amino acids 301/407 (the bHLH/leucine zipper domain) of human SREBP-1.
Applications
Application Notes
Flow Cyt: 1μg/106 cells; ICC/IF: 5 μg/ml; WB: 1 - 2 μg/ml.
Target
Alternative Names
SREBF1; sterol regulatory element binding transcription factor 1; sterol regulatory element-binding protein 1; bHLHd1; SREBP 1c; SREBP1; SREBP-1; class D basic helix-loop-helix protein 1; SREBP-1c;
Product Background
Antigen Description
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5-ATCACCCCAC-3). Has dual sequence specificity binding to both an E-box motif (5-ATCACGTGA-3) and to SRE-1 (5-ATCACCCCAC-3).
Pathway
Adipogenesis, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Id Signaling Pathway, organism-specific biosystem; Insulin signaling pathway, organism-specific biosystem.
Citations
Publication ()
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COA
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