Anti-SPTBN2 (aa 643-720) polyclonal antibody

Species Reactivity

Human

Immunogen

SPTBN2 (NP_008877, 643 a.a. ~ 720 a.a) partial recombinant protein with GST tag. The sequence is LWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLE QGQQLVAEGHPGASQASA

Conjugate

Alternative Names

SPTBN2; spectrin, beta, non-erythrocytic 2; SCA5; SCAR14; GTRAP41; spectrin beta chain, non-erythrocytic 2; beta-III spectrin; spectrin beta III sigma 2; spectrin beta chain, brain 2; spinocerebellar ataxia 5 protein; spectrin, non-erythroid beta chain 2;

Entrez Gene ID

UniProt ID

Antigen Description

Spectrins are principle components of a cells membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.

Pathway

Adaptive Immune System; Developmental Biology; Interaction between L1 and Ankyrins; MHC class II antigen presentation.