General Notes
This product (Catalog No. DPABH-00567) is a rabbit-derived polyclonal antibody raised against human SPOP, targeting the amino acid region 41–90 of the protein. This antibody exhibits cross-reactivity with SPOP from mouse and rat. It has been affinity purified by Protein A. This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.
DPABH-00567 is suitable for use in Western blot (WB) (1:500–1:2,000), IHC (1:100–1:300) applications.
DPABH-00567 is supplied as a liquid formulation in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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