Anti-SPON1 polyclonal antibody (DPABH-08849)

Rabbit Anti-Human SPON1 (aa 14-44) polyclonal antibody for IHC-P, WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Mouse, Human
Immunogen
Synthetic peptide within Human SPON1 aa 14-44 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q9HCB6
Conjugate
Unconjugated

Applications


Application Notes
IHC-P: 1/10 - 1/50; WB: 1/100 - 1/500.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
SPON1; spondin 1, extracellular matrix protein; spondin 1, (f spondin) extracellular matrix protein; spondin-1; f spondin; KIAA0762
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
SPON1 is a member of a subgroup of the thrombospondin type 1 (TSR) class molecules, defined by two domains of homology, the FS1/FS2 and TSR domains. The TSRs of SPON1 proteins are typical of class 2 TSRs. SPON1, which is similar to thrombospondin, is a extracellular matrix attached molecule that promotes neurite outgrowth and inhibits angiogenesis. Analysis of gain and loss of function experiments reveal that SPON1 is required for accurate pathfinding of embryonic axons, and plays a dual role in patterning axonal trajectories. It promotes the outgrowth of commissural and inhibits the outgrowth of motor axons, and has also been implicated in inflammatory processes in the nervous system. Spondin-1 (also known as F-spondin) is a protein that in humans is encoded by the SPON1 gene. It is secreted by cells of the floor plate and may be involved in axon guidance The protein contains 807 aminoacids and is structurally composed of six thrombospondin domains, one reelin domain, and one spondin domain. 0The function about SPON1 antigen include protein binding.

Citations


Have you cited DPABH-08849 in a publication? Let us know and earn a reward for your research.

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

Customer Reviews


Write a review, share your experiences with others and get rewarded !
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket

Online Inquiry

Name:
Phone: *
E-mail Address: *
Service & Products Interested: *
Project Description:
Verification Code: * Please input "diagnostics" as verification code.

Online Inquiry

  Interested in larger quantities ? request a quote!
  Protocol may be improved. Please feel free to contact us to obtain the latest version.!

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

OUR PROMISE TO YOU Guaranteed product quality expert customer support

Inquiry Basket