Full length protein corresponding to Human SPHK1 aa 1-398.Sequence: MDPVVGCGRGLFGFVFSAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRS HVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHE VVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLT NCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLA
Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra-and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.
Pathway
Association of TriC/CCT with target proteins during biosynthesis; Calcium signaling pathway; Chaperonin-mediated protein folding; Fc gamma R-mediated phagocytosis; Fc-epsilon receptor I signaling in mast cells;
Citations
Publication ()
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