Specifications
Immunogen
SPG11 antibody was raised against a 15 amino acid peptide of human SPG11.
Target
Alternative Names
SPG11; spastic paraplegia 11 (autosomal recessive); KIAA1840; spatacsin; spastic paraplegia 11 protein; colorectal carcinoma-associated protein
Product Background
Antigen Description
The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Murmu, RP; Martin, E; et al. Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia. MOLECULAR AND CELLULAR NEUROSCIENCE 47:191-202(2011).
Kuru, S; Yoshida, M; et al. Immunohistochemical localization of spatacsin in alpha-synucleinopathies. NEUROPATHOLOGY 34:135-139(2014).
COA
Certificate of Analysis
