Rabbit Anti-Human SPAG8 (internal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Fusion protein corresponding to a region derived from internal residues of human sperm associated antigen 8

Conjugate

Application Notes

IHC: 1:25-1:100

General Notes

This product (Catalog No. DPABH-03874) is a rabbit-derived IgG polyclonal antibody raised against human SPAG8. It has been affinity purified by protein A. The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.
DPABH-03874 is suitable for use in IHC (1:25–1:100) application.
DPABH-03874 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

SMP1; BS-84; HSD-1; SPAG3; hSMP-1

Entrez Gene ID

UniProt ID