Anti-SPAG1 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 131-159 (VRGSNSCLHVGKEKYSKRPTKKKTPRDYA) of Human spag1 (UniProt ID: Q07617).

Conjugate

Unconjugated

Application Notes

WB: 1/100 - 1/500; IHC-P: 1/50 - 1/100;

Alternative Names

SPAG1; sperm associated antigen 1; SP75; TPIS; CT140; CILD28; HSD-3.8; sperm-associated antigen 1; infertility-related sperm protein Spag-1; tetratricopeptide repeat-containing protein; TPR-containing protein involved in spermatogenesis;

Entrez Gene ID

6674

UniProt ID

Q07617

Antigen Description

Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.

We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More