Acyl-coenzyme A: cholesterol acyltransferase 2 (SOAT2/ACAT2) catalyzes the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A. It is associated with lipoprotein particle secretion and thus plays an important role in the metabolism of triglyceride-rich lipoproteins like ApoB100. In humans, ACAT2 is primarily expressed in the small intestine, whereas in other mammals, the enzyme is expressed in the liver and the small intestine. Human ACAT2 has 522 amino acids with an estimated molecular weight of 60 kDa
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