This gene encodes a member of the sorting nexin family.Members of this family contain a phox (PX) domain, which is aphosphoinositide binding domain, and are involved in intracellulartrafficking. This protein associates with the long isoform of theleptin receptor, the transforming growth factor-beta family ofreceptor serine-threonine kinases, and with receptor tyrosinekinases for platelet-derived growth factor, insulin, and epidermalgrowth factor. This protein may form oligomeric complexes withfamily member proteins through interactions of both the PX domainand the coiled coil regions of the molecules. Translocation of thisprotein from the cytoplasm to the nucleus occurs after binding toproviral integration site 1 protein. This gene results in twotranscripts encoding two distinct isoforms.
Pathway
TGF-beta Receptor Signaling Pathway.
Citations
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