Specifications
Immunogen
SMO (NP_005622, 56 a.a. ~ 155 a.a) partial recombinant protein with GST tag. The sequence is GPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNA PRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCA
Target
Alternative Names
SMO; smoothened, frizzled class receptor; Gx; SMOH; FZD11; smoothened homolog; protein Gx; frizzled family member 11; seven transmembrane helix receptor; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor;
Product Background
Antigen Description
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex.
Pathway
Basal cell carcinoma; Class B/2 (Secretin family receptors); GPCRs, Other; Hedgehog signaling events mediated by Gli proteins
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Outram, SV; Varas, A; et al. Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte. IMMUNITY 13:187-197(2000).
Russell, MC; Cowan, RG; et al. The hedgehog signaling pathway in the mouse ovary. BIOLOGY OF REPRODUCTION 77:226-236(2007).
COA
Certificate of Analysis
