Specifications
Immunogen
Recombinant fragment, corresponding to a region within amino acids 719-1003 of Human SMG7, isoform 4 (AAH36381).
Applications
Application Notes
WB: 1/500 - 1/3000; IHC-P: 1/100 - 1/500.
Target
Alternative Names
SMG7; smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans); C1orf16, chromosome 1 open reading frame 16; protein SMG7; EST1 telomerase component homolog C (S. cerevisiae); EST1C; KIAA0250; SGA56M; SMG 7; EST1-like protein C; ever shorter telome
Product Background
Antigen Description
SMG7 plays a role in nonsense-mediated mRNA decay. It recruits RENT1 to cytoplasmic mRNA decay bodies. It acts as part of a complex that contains SMG5, SMG7, PP2AC, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated RENT1.
Pathway
Gene Expression; Nonsense Mediated Decay Enhanced by the Exon Junction Complex; Nonsense-Mediated Decay; mRNA surveillance pathway;
Citations
Publication ()
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COA
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