Anti-SMARCD3 (aa 128-177) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Human

Immunogen

A region within synthetic peptide: FERKLDQTIM RKRVDIQEAL KRPMKQKRKL RLYISNTFNP AKPDAEDSDG, corresponding to amino acids 128-177 of Human SMARCD3

Conjugate

Application Notes

WB: 0.5 μg/ml; ELISA: 1/1562500.

Alternative Names

SMARCD3; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3; 60kDa BRG 1/Brm associated factor subunit c; BAF60C;

Entrez Gene ID

UniProt ID

Antigen Description

Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

Pathway

BMAL1:CLOCK/NPAS2 Activates Circadian Expression; Circadian Clock; Circadian Repression of Expression by REV-ERBA; Developmental Biology; Fatty acid, triacylglycerol, and ketone body metabolism; Gene Expression; Generic Transcription Pathway