Anti-SMARCC1 monoclonal antibody, clone FQS23406

Antibody Isotype

IgG

Clone

FQS23406

Species Reactivity

Rat; Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human SMARCC1 aa 700-800 (Cysteine residue). The exact sequence is proprietary.Database link: Q92922

Conjugate

Application Notes

WB: 1/1000 - 1/10000; ICC/IF: 1/250 - 1/500; IP: 1/10 - 1/100; Flow Cyt: 1/10 - 1/100.

Alternative Names

SMARCC1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1; SWI/SNF complex subunit SMARCC1; BAF155; CRACC1; Rsc8; SRG3; BRG1-associated factor 155; SWI/SNF complex 155 kDa subunit; chromatin remodeling comp

Entrez Gene ID

UniProt ID

Antigen Description

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

Pathway

Glucocorticoid receptor regulatory network, organism-specific biosystem; Regulation of Androgen receptor activity, organism-specific biosystem; TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem;