Anti-SLIT1 monoclonal antibody, clone FQ6808(3)

Antibody Isotype

IgG

Clone

FQ6808(3)

Species Reactivity

Human

Immunogen

Synthetic peptide, corresponding to residues in Human Slit1 (UniProt: O75093).

Conjugate

Application Notes

WB: 1/1000 - 1/10000.

Alternative Names

SLIT1; slit homolog 1 (Drosophila); SLIL1, slit (Drosophila) homolog 1; slit homolog 1 protein; MEGF4; Slit 1; slit1; SLIT3; multiple EGF-like domains protein 4; multiple epidermal growth factor-like domains protein 4; SLIL1; SLIT-1; MGC164811;

Entrez Gene ID

UniProt ID

Antigen Description

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.

Pathway

Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Netrin-1 signaling, organism-specific biosystem;