SLCO1B1 (NP_006437, 481 a.a. ~ 570 a.a) partial recombinant protein with GST tag. The sequence is YISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAI QVLNLFFSALGGTSHVMLIVKIVQPELKSL
Conjugate
Unconjugated
Target
Alternative Names
SLCO1B1; solute carrier organic anion transporter family, member 1B1; LST1; HBLRR; LST-1; OATP2; OATPC; OATP-C; OATP1B1; SLC21A6; solute carrier organic anion transporter family member 1B1; OATP-2; solute carrier family 21 member 6; liver-specific organic
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function.
Pathway
Bile acid and bile salt metabolism; Bile secretion; Drug Induction of Bile Acid Pathway; Metabolism of lipids and lipoproteins.
Citations
Publication ()
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