Anti-SLC7A8 monoclonal antibody, clone 9C23

Antibody Isotype

IgG1

Clone

9C23

Species Reactivity

Human

Immunogen

Recombinant Human LAT2 protein expressed in 293T cells.

Conjugate

Application Notes

WB: 1/500; IHC-P: 1/50;

Alternative Names

SLC7A8; solute carrier family 7 (amino acid transporter light chain, L system), member 8; large neutral amino acids transporter small subunit 2; LAT2; LPI PC1; hLAT2; integral membrane protein E16H; L-type amino acid transporter 2; solute carrier family 7

Entrez Gene ID

UniProt ID

Antigen Description

Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.

Pathway

Amino acid transport across the plasma membrane, organism-specific biosystem; Basigin interactions, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem; Protein digestion and absorption, organism-specific biosystem; Protein digestion and absorption, conserved biosystem; SLC-mediated transmembrane transport, organism-specific biosystem.