Anti-SLC4A3 polyclonal antibody (DPABH-22858)


Host Species
Antibody Isotype
Species Reactivity
antigen sequence: FQRELLRKRR EREQTKVEMT TRGGYTAPGK ELSLELGGSE ATPEDDPLLR TGSVFG, corresponding to amino acids of Human SLC4A3.


Application Notes
WB: 1/100 - 1/250. IHC-P: 1/200 - 1/500.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.


Alternative Names
SLC4A3; solute carrier family 4 (anion exchanger), member 3; AE3; SLC2C; anion exchange protein 3; AE 3
Entrez Gene ID
UniProt ID

Product Background

Antigen Description
SLC4A3 (solute carrier family 4 (anion exchanger), member 3) is a protein-coding gene. Diseases associated with SLC4A3 include dendritic cell thymoma , and alveolar echinococcosis , and among its related super-pathways are Transmembrane transport of small molecules and Amino acid and oligopeptide SLC transporters. GO annotations related to this gene include inorganic anion exchanger activity. An important paralog of this gene is SLC4A10. Anion exchange protein 3 is a membrane transport protein that in humans is encoded by the SLC4A3 gene. AE3 is functionally similar to the Band 3 Cl−/HCO3− exchange protein but it is expressed primarily in brain neurons and in the heart. Like AE2 its activity is sensitive to pH. AE3 mutations have been linked to seizures. 0The function about SLC4A3 antigen include inorganic anion exchanger activity.
Bicarbonate transporters; Transmembrane transport of small molecules.


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Aiba, Y; Nakamura, M; et al. Genetic polymorphisms in CTLA4 and SLC4A2 are differentially associated with the pathogenesis of primary biliary cirrhosis in Japanese patients. JOURNAL OF GASTROENTEROLOGY 46:1203-1212(2011).
Chen, LM; Kelly, ML; et al. Expression and localization of Na-driven Cl-HCO3- exchanger (SLC4A8) in rodent CNS. NEUROSCIENCE 153:162-174(2008).

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