Anti-SLC4A3 polyclonal antibody (DPABH-22858)

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
antigen sequence: FQRELLRKRR EREQTKVEMT TRGGYTAPGK ELSLELGGSE ATPEDDPLLR TGSVFG, corresponding to amino acids of Human SLC4A3.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/100 - 1/250. IHC-P: 1/200 - 1/500.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
SLC4A3; solute carrier family 4 (anion exchanger), member 3; AE3; SLC2C; anion exchange protein 3; AE 3
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
SLC4A3 (solute carrier family 4 (anion exchanger), member 3) is a protein-coding gene. Diseases associated with SLC4A3 include dendritic cell thymoma , and alveolar echinococcosis , and among its related super-pathways are Transmembrane transport of small molecules and Amino acid and oligopeptide SLC transporters. GO annotations related to this gene include inorganic anion exchanger activity. An important paralog of this gene is SLC4A10. Anion exchange protein 3 is a membrane transport protein that in humans is encoded by the SLC4A3 gene. AE3 is functionally similar to the Band 3 Cl−/HCO3− exchange protein but it is expressed primarily in brain neurons and in the heart. Like AE2 its activity is sensitive to pH. AE3 mutations have been linked to seizures. 0The function about SLC4A3 antigen include inorganic anion exchanger activity.
Pathway
Bicarbonate transporters; Transmembrane transport of small molecules.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Chen, LM; Kelly, ML; et al. Expression and localization of Na-driven Cl-HCO3- exchanger (SLC4A8) in rodent CNS. NEUROSCIENCE 153:162-174(2008).
Aiba, Y; Nakamura, M; et al. Genetic polymorphisms in CTLA4 and SLC4A2 are differentially associated with the pathogenesis of primary biliary cirrhosis in Japanese patients. JOURNAL OF GASTROENTEROLOGY 46:1203-1212(2011).

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