Anti-SLC27A5 monoclonal antibody, clone DM1324

Antibody Isotype

IgG1

Clone

DM1324

Species Reactivity

Human

Immunogen

Recombinant fragment corresponding to amino acids 223-345 of Human SLC27A5 (UniProt ID: Q9Y2P5).

Conjugate

Application Notes

IHC-P: 1/500 - 1/1000; WB: 1/1000 - 1/2500.

Alternative Names

SLC27A5; solute carrier family 27 (fatty acid transporter), member 5; bile acyl-CoA synthetase; ACSB; ACSVL6; FACVL3; FATP5; fatty acid Coenzyme A ligase; very long chain 3; FLJ22987; VLACSR; VLCS H2; VLCSH2; BA-CoA ligase; VLACS-related; cholate--CoA lig

Entrez Gene ID

UniProt ID

Antigen Description

Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.

Pathway

Bile acid and bile salt metabolism, organism-specific biosystem; Bile acid biosynthesis, cholesterol => cholate, organism-specific biosystem; Bile acid biosynthesis, cholesterol => cholate, conserved biosystem; Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem;