Anti-SLC22A5 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human SLC22A5 is used for rabbit immunization.

Conjugate

Alternative Names

SLC22A5; solute carrier family 22 (organic cation/carnitine transporter), member 5; CDSP; OCTN2; OCTN2VT; solute carrier family 22 member 5; organic cation/carnitine transporter 2; high-affinity sodium dependent carnitine cotransporter;

Entrez Gene ID

UniProt ID

Antigen Description

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy.

Pathway

Organic cation transport; Organic cation/anion/zwitterion transport; SLC-mediated transmembrane transport; Transmembrane transport of small molecules; Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds;