Anti-SLC19A1 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human SLC19A1 is used for rabbit immunization.

Conjugate

Alternative Names

SLC19A1; solute carrier family 19 (folate transporter), member 1; folate transporter 1; FOLT; RFC; IFC-1; intestinal folate carrier 1; placental folate transporter; reduced folate carrier protein; solute carrier family 19 member 1; CHMD; IFC1; REFC; RFC1;

Entrez Gene ID

UniProt ID

Antigen Description

Transport of folate compounds into mammalian cells can occur via receptor-mediated (see MIM 136430) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.

Pathway

Metabolism, organism-specific biosystem; Metabolism of folate and pterines, organism-specific biosystem; Metabolism of vitamins and cofactors, organism-specific biosystem; Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem; Vitamin digestion and absorption, organism-specific biosystem; Vitamin digestion and absorption, conserved biosystem;