Potassium-chloride cotransporters mediate the coupled movement of potassium and chloride ions across the plasma membrane. SLC12A4 mediates electroneutral potassium-chloride cotransport when activated by cell swelling and may contribute to cell volume homeostasis in single cells. SLC12A4 may play a role in early erythroid maturation events.
Pathway
Cation-coupled Chloride cotransporters; SLC-mediated transmembrane transport; Transmembrane transport of small molecules; Transport of inorganic cations/anions and amino acids/oligopeptides;
Citations
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