Synthetic peptide within Human NRAMP1 aa 256-285 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: P49279
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/1000; ICC/IF: 1/10 - 1/50;
Target
Alternative Names
SLC11A1; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1; LSH; NRAMP; NRAMP1; natural resistance-associated macrophage protein 1; NRAMP 1; solute carrier family 11 member 1; solute carrier family 11 (sodium/phosphate sym
Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
Pathway
Disease; Lysosome; Metal ion SLC transporters; Mineral absorption
Citations
Publication ()
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COA
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