Anti-SKIV2L monoclonal antibody, clone 2F6

Antibody Isotype

IgG2a

Clone

2F6

Species Reactivity

Human

Immunogen

SKIV2L (NP_008860, 1125 a.a. ~ 1233 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

SKIV2L; superkiller viralicidic activity 2-like (S. cerevisiae); SKIV2, superkiller viralicidic activity 2 (S. cerevisiae homolog) like; helicase SKI2W; 170A; DDX13; HLP; SKI2W; helicase-like protein; SKI2; SKIV2; THES2;

Entrez Gene ID

UniProt ID

Antigen Description

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a human homologue of yeast SKI2 and may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene is located in the class III region of the major histocompatibility complex.

Pathway

Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystem; Chaperonin-mediated protein folding, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; Protein folding, organism-specific biosystem; RNA degradation, organism-specific biosystem; RNA degradation, conserved biosystem; Ski complex, organism-specific biosystem;