Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Pathway
BDNF signaling pathway; Cell surface interactions at the vascular wall; Hemostasis; Osteoclast differentiation
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Asami, R; Azuma, T; et al. Tumor enhanced imaging and treatment with targeted phase-change nano particles. 2007 IEEE ULTRASONICS SYMPOSIUM PROCEEDINGS, VOLS 1-6 :1973-1976(2007).
Bodart, V; Rainey, WE; et al. The H295R human adrenocortical cell line contains functional atrial natriuretic peptide-receptors that inhibit aldosterone biosynthesis. MOLECULAR AND CELLULAR ENDOCRINOLOGY 118:137-144(1996).
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COA
Certificate of Analysis
