Anti-GEMIN2 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human SIP1 is used for rabbit immunization.

Conjugate

Alternative Names

GEMIN2; gem (nuclear organelle) associated protein 2; SIP1; SIP1-delta; gem-associated protein 2; gemin-2; component of gems 2; SMN interacting protein 1-delta; survival of motor neuron protein interacting protein 1;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.

Pathway

Gene Expression; Metabolism of non-coding RNA; RNA transport; Survival motor neuron (SMN) complex; Survival motor neuron (SMN) complex; snRNP Assembly;